RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Ptpa
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
NA
Pathway
PP2A/HISTONE DEACETYLASE C4/MICRORNA-29 signaling pathway
PubMed ID
Title
Pathologic Regulation of Collagen I by an Aberrant Protein Phosphatase 2A/Histone Deacetylase C4/MicroRNA-29 Signal Axis in Idiopathic Pulmonary Fibrosis Fibroblasts
Year
2015
Function
"The mechanism for suppression of miR-29 during IPF fibroblast interaction with polymerized collagen involves inappropriately low protein phosphatase (PP) 2A function, leading to histone deacetylase (HDA) C4 phosphorylation and decreased nuclear translocation of HDAC4.PF fibroblast interaction with polymerized type I collagen results in an aberrant PP2A/HDAC4 axis, which suppresses miR-29, causing a pathologic increase in type I collagen expression."